Indian hedgehog coordinates endochondral bone growth and morphogenesis via parathyroid hormone related-protein-dependent and -independent pathways

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Amizuka, N., Henderson J. E., Hoshi, K., Warshawsky, H., Ozawa, H., Goltzman, D. and Karaplis, A. C (1996). Programmed cell death ofchondrocytes and aberrant chondrogenesis in mice homozygous for Parathyroid Hormone-related Peptide gene deletion. Endocrinology 137, 5055-5067.[Abstract]

Bitgood, M. J. and McMahon, A. P (1995). Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev. Biol 172, 126-138.[Medline]

Cheah, K. S., Lau, E. T., Au, P. K. and Tam, P. P (1991). Expression of the mouse alpha 1(II) collagen gene is not restricted to cartilage during development. Development 111, 945-53.[Abstract/Free Full Text]

Echelard Y., Epstein, D. J., St-Jacques, B., Shen, L., Mohler, J., McMahon, J. A. and McMahon, A. P (1993). Sonic hedgehog , a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 75, 1417-30.[Medline]

Elima, K., Eerola, I., Rosati, R., Metsaranta, M., Garofalo, S., Perala, M., De Crombrugghe, B. and Vuorio, E (1993). The mouse collagen X gene: complete nucleotide sequence, exon structure and expression pattern. Biochem. J 289, 247-253.

Erlebacher, A., Filvaroff, E. H., Gitelman, S. E. and Derynck, R (1995). Toward a molecular understanding of skeletal development. Cell 80, 371-378.[Medline]

Hunziker, E. B (1988). Growth plate structure and function. Pathol. Immunopathol. Res 7, 9-13.[Medline]

Karaplis, A. C., Luz, A., Glowacki, J., Bronson, R. T., Tybulewicz, V. L., Kronenberg, H. M. and Mulligan, R. C (1994). Lethal skeletal dysplasia from targeted disruption of the Parathyroid Hormone-related Peptide gene. Genes Dev 8, 277-289.[Abstract/Free Full Text]

Kosher, R. A., Kulyk, W. M. and Gay, S. W (1986). Collagen gene expression during cartilage differentiation. J. Cell Biol 102, 1151-1156.[Abstract/Free Full Text]

Lanske, B., Karaplis, A. C., Lee, K., Luz, A., Vortkamp, A., Pirro, A., Karperien, M., Defize, L. H. K., Ho, C., Mulligan, R. C., Abou-Samra, A. B., Juppner, H., Segre, G. V. and Kronenberg, H. M (1996). PTH/ PTHrP receptor in early development and Indian hedgehog-regulated bone growth. Science 273, 663-666.[Abstract]

Lee, K., Deeds, J. D. and Segre, G. V (1995). Expression of Parathyroid Hormone-related Peptide and its receptor messenger ribonucleic acids during fetal development of rats. Endocrinology 136, 453-463.[Abstract]

Lee, K., Lanske, B., Karaplis, A. C., Deeds, J. D., Kohno, H., Nissenson, R. A., Kronenberg, H. M. and Segre, G. V (1996). Parathyroid hormone-related Peptide delays terminal differentiation of chondrocytes during endochondral bone development. Endocrinology 137, 5109-5118.[Abstract]

Metsaranta M., Garofalo, S., Smith, C., Niederreither, K., de Crombrugghe, B. and Vuorio, E (1995). Developmental expression of a type II collagen/ beta-galactosidase fusion gene in transgenic mice. Dev. Dyn 204, 202-10.[Medline]

McLeod, M. J (1980). Differential staining of cartilage and bone in whole mouse fetuses by alcian blue and alizarin red S. Teratology 22, 299-301.[Medline]

Nowakowski, R. S., Lewin, S. B. and Miller, M. W (1989). Bromodeoxyuridine immunohistochemical determination of the lengths of the cell cycle and the DNA-synthetic phase for an anatomically defined population. J. Neurocytol 18, 311-318.[Medline]

Schipani, E., Kruse, K. and Juppner, H (1995). A constitutively active mutant PTH- PTHrP receptor in Jansen-type metaphyseal chondrodysplasia. Science 268, 98-100.[Abstract/Free Full Text]

Schipani, E., Lanske, B., Hunzelman, J., Luz, A., Kovacs, C. S., Lee, K., Pirro, A., Kronenberg, H. M. and Juppner, H (1997). Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid hormone-related peptide. Proc. Natl. Acad. Sci. USA 94, 13689-13694.[Abstract/Free Full Text]

St-Jacques, B., Hammerschmidt, M., McMahon, A. P (1999). Indian hedgehog signaling regulates proliferation and differentiation of the chondrocytes and is essential for osteoblast differentiation during skeletal development. Genes Dev 13, 2072-2086.[Abstract/Free Full Text]

Suva, L. J.,Winslow, G. A., Wettenhall, R. E. H., Hammonds, R. G., Moseley, J. M., Diefenbach-Jagger, H., Rodda, C., Kemp, P. B. E., Rodriguez, H., Chen, E. Y., Hudson, P. J., Martin, T. J. and Wood, W. I (1987). A Parathyroid Hormone-related Protein implicated in malignant hypercalcemia: cloning and expression. Science 237, 893-896.[Abstract/Free Full Text]

Swalla, B. J., Upholt, W. B. and Solursh. M (1988). Analysis of type II collagen RNA localization in chick wing buds by in situ hybridization. Dev. Biol 125, 51-58.[Medline]

Vortkamp, A., Lee, K., Lanske, B., Segre, G. V., Kronenberg, H. M. and Tabin, C. J (1996). Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science 273, 613-622.[Abstract]

Weir, E. C., Philbrick, W. M., Amling, M., Neff, L. A., Baron, R. and Broadus, A. E (1996). Targeted overexpression of Parathyroid Hormone-related Peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation. Proc. Natl. Acad. Sci. USA 93, 10240-10245.[Abstract/Free Full Text]

Yamada, Y., Miyashita, T., Savagner, P., Horton, W., Brown, K. S., Amramczuk, J., Xie, H. X., Kohno, K., Bolander, M. and Bruggeman, L (1990). Regulation of the collagen II gene in vitro and in transgenic mice. Ann. N. Y. Acad. Sci 580, 81-87.[Medline]

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				K. K. Mak, H. M. Kronenberg, P.-T. Chuang, S. Mackem, and Y. Yang Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy Development, June 1, 2008; 135(11): 1947 - 1956. [Abstract] [Full Text] [PDF]

				T. Kobayashi, J. Lu, B. S. Cobb, S. J. Rodda, A. P. McMahon, E. Schipani, M. Merkenschlager, and H. M. Kronenberg Dicer-dependent pathways regulate chondrocyte proliferation and differentiation PNAS, February 12, 2008; 105(6): 1949 - 1954. [Abstract] [Full Text] [PDF]

				S. Provot, G. Nachtrab, J. Paruch, A. P. Chen, A. Silva, and H. M. Kronenberg A-Raf and B-Raf Are Dispensable for Normal Endochondral Bone Development, and Parathyroid Hormone-Related Peptide Suppresses Extracellular Signal-Regulated Kinase Activation in Hypertrophic Chondrocytes Mol. Cell. Biol., January 1, 2008; 28(1): 344 - 357. [Abstract] [Full Text] [PDF]

				A. Abzhanov, S. J. Rodda, A. P. McMahon, and C. J. Tabin Regulation of skeletogenic differentiation in cranial dermal bone Development, September 1, 2007; 134(17): 3133 - 3144. [Abstract] [Full Text] [PDF]

				C. J. Haycraft, Q. Zhang, B. Song, W. S. Jackson, P. J. Detloff, R. Serra, and B. K. Yoder Intraflagellar transport is essential for endochondral bone formation Development, January 15, 2007; 134(2): 307 - 316. [Abstract] [Full Text] [PDF]

				B. S. Yoon, R. Pogue, D. A. Ovchinnikov, I. Yoshii, Y. Mishina, R. R. Behringer, and K. M. Lyons BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways Development, December 1, 2006; 133(23): 4667 - 4678. [Abstract] [Full Text] [PDF]

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				K. K. Mak, M.-H. Chen, T. F. Day, P.-T. Chuang, and Y. Yang Wnt/{beta}-catenin signaling interacts differentially with Ihh signaling in controlling endochondral bone and synovial joint formation Development, September 15, 2006; 133(18): 3695 - 3707. [Abstract] [Full Text] [PDF]

				J. A. Sterling, B. O. Oyajobi, B. Grubbs, S. S. Padalecki, S. A. Munoz, A. Gupta, B. Story, M. Zhao, and G. R. Mundy The hedgehog signaling molecule gli2 induces parathyroid hormone-related Peptide expression and osteolysis in metastatic human breast cancer cells. Cancer Res., August 1, 2006; 66(15): 7548 - 7553. [Abstract] [Full Text] [PDF]

				D. Spater, T. P. Hill, R. J. O'Sullivan, M. Gruber, D. A. Conner, and C. Hartmann Wnt9a signaling is required for joint integrity and regulation of Ihh during chondrogenesis Development, August 1, 2006; 133(15): 3039 - 3049. [Abstract] [Full Text] [PDF]

				J. H. D. Bassett, R. Swinhoe, O. Chassande, J. Samarut, and G. R. Williams Thyroid Hormone Regulates Heparan Sulfate Proteoglycan Expression in the Growth Plate Endocrinology, January 1, 2006; 147(1): 295 - 305. [Abstract] [Full Text] [PDF]

				L. Koziel, M. Wuelling, S. Schneider, and A. Vortkamp Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation Development, December 1, 2005; 132(23): 5249 - 5260. [Abstract] [Full Text] [PDF]

				H. M. Kronenberg How PTHrP Controls Growth Plate Chondrocytes IBMS BoneKEy, November 1, 2005; 2(11): 7 - 15. [Full Text] [PDF]

				M. J. Hilton, X. Tu, J. Cook, H. Hu, and F. Long Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development Development, October 1, 2005; 132(19): 4339 - 4351. [Abstract] [Full Text] [PDF]

				B. D. Harfe, M. T. McManus, J. H. Mansfield, E. Hornstein, and C. J. Tabin The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb PNAS, August 2, 2005; 102(31): 10898 - 10903. [Abstract] [Full Text] [PDF]

				T. Kobayashi and H. Kronenberg Minireview: Transcriptional Regulation in Development of Bone Endocrinology, March 1, 2005; 146(3): 1012 - 1017. [Abstract] [Full Text] [PDF]

				A. Kato, M. Suzuki, Y. Karasawa, T. Sugimoto, and K. Doi Histopathological Study of Time Course Changes in PTHrP-Induced Incisor Lesions of Rats Toxicol Pathol, February 1, 2005; 33(2): 230 - 238. [Abstract] [Full Text] [PDF]

				H. Tian, J. Jeong, B. D. Harfe, C. J. Tabin, and A. P. McMahon Mouse Disp1 is required in sonic hedgehog-expressing cells for paracrine activity of the cholesterol-modified ligand Development, January 1, 2005; 132(1): 133 - 142. [Abstract] [Full Text] [PDF]

				H. Tian, T. Tenzen, and A. P. McMahon Dose dependency of Disp1 and genetic interaction between Disp1 and other hedgehog signaling components in the mouse Development, August 15, 2004; 131(16): 4021 - 4033. [Abstract] [Full Text] [PDF]

				F. Long, U.-i. Chung, S. Ohba, J. McMahon, H. M. Kronenberg, and A. P. McMahon Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton Development, March 15, 2004; 131(6): 1309 - 1318. [Abstract] [Full Text] [PDF]

				S. Wu and F. De Luca Role of Cholesterol in the Regulation of Growth Plate Chondrogenesis and Longitudinal Bone Growth J. Biol. Chem., February 6, 2004; 279(6): 4642 - 4647. [Abstract] [Full Text] [PDF]

				A. M. Boulet and M. R. Capecchi Multiple roles of Hoxa11 and Hoxd11 in the formation of the mammalian forelimb zeugopod Development, January 15, 2004; 131(2): 299 - 309. [Abstract] [Full Text] [PDF]

				B. C. J. van der Eerden, M. Karperien, and J. M. Wit Systemic and Local Regulation of the Growth Plate Endocr. Rev., December 1, 2003; 24(6): 782 - 801. [Abstract] [Full Text] [PDF]

				P. G. Buxton, B. Hall, C. W. Archer, and P. Francis-West Secondary chondrocyte-derived Ihh stimulates proliferation of periosteal cells during chick development Development, October 1, 2003; 130(19): 4729 - 4739. [Abstract] [Full Text] [PDF]

				P. J. O'Shea, C. B. Harvey, H. Suzuki, M. Kaneshige, K. Kaneshige, S.-Y. Cheng, and G. R. Williams A Thyrotoxic Skeletal Phenotype of Advanced Bone Formation in Mice with Resistance to Thyroid Hormone Mol. Endocrinol., July 1, 2003; 17(7): 1410 - 1424. [Abstract] [Full Text] [PDF]

				B. Scheijen, M. Bronk, T. van der Meer, and R. Bernards Constitutive E2F1 Overexpression Delays Endochondral Bone Formation by Inhibiting Chondrocyte Differentiation Mol. Cell. Biol., May 15, 2003; 23(10): 3656 - 3668. [Abstract] [Full Text] [PDF]

				V. Church, T. Nohno, C. Linker, C. Marcelle, and P. Francis-West Wnt regulation of chondrocyte differentiation J. Cell Sci., March 14, 2003; 115(24): 4809 - 4818. [Abstract] [Full Text] [PDF]

				J. Yu, T. J. Carroll, and A. P. McMahon Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney Development, March 13, 2003; 129(22): 5301 - 5312. [Abstract] [Full Text] [PDF]

				T. Kobayashi, U.-i. Chung, E. Schipani, M. Starbuck, G. Karsenty, T. Katagiri, D. L. Goad, B. Lanske, and H. M. Kronenberg PTHrP and Indian hedgehog control differentiation of growth plate chondrocytes at multiple steps Development, March 8, 2003; 129(12): 2977 - 2986. [Abstract] [Full Text] [PDF]

				N. Byrd, S. Becker, P. Maye, R. Narasimhaiah, B. St-Jacques, X. Zhang, J. McMahon, A. McMahon, and L. Grabel Hedgehog is required for murine yolk sac angiogenesis Development, March 3, 2003; 129(2): 361 - 372. [Abstract] [Full Text] [PDF]