Ligand endocytosis drives receptor dissociation and activation in the Notch pathway

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D. A. Dansereau, M. D. Lunke, A. Finkielsztein, M. A. Russell, and W. J. Brook
hephaestus encodes a polypyrimidine tract binding protein that regulates Notch signalling during wing development in Drosophila melanogaster
Development, March 14, 2003; 129(24): 5553 - 5566.
[Abstract] [Full Text] [PDF]

Q. Shen and S. Temple
Creating Asymmetric Cell Divisions by Skewing Endocytosis
Sci. Signal., December 10, 2002; 2002(162): pe52 - pe52.
[Abstract] [Full Text] [PDF]

K. Mishra-Gorur, M. D. Rand, B. Perez-Villamil, and S. Artavanis-Tsakonas
Down-regulation of Delta by proteolytic processing
J. Cell Biol., October 28, 2002; 159(2): 313 - 324.
[Abstract] [Full Text] [PDF]

				W. R. Gordon, K. L. Arnett, and S. C. Blacklow The molecular logic of Notch signaling - a structural and biochemical perspective J. Cell Sci., October 1, 2008; 121(19): 3109 - 3119. [Abstract] [Full Text] [PDF]

				S. F. Heuss, D. Ndiaye-Lobry, E. M. Six, A. Israel, and F. Logeat The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity PNAS, August 12, 2008; 105(32): 11212 - 11217. [Abstract] [Full Text] [PDF]

				S. H. Eun, S. M. L. Banks, and J. A. Fischer Auxilin is essential for Delta signaling Development, March 15, 2008; 135(6): 1089 - 1095. [Abstract] [Full Text] [PDF]

				S. Bai, R. Kopan, W. Zou, M. J. Hilton, C.-t. Ong, F. Long, F. P. Ross, and S. L. Teitelbaum NOTCH1 Regulates Osteoclastogenesis Directly in Osteoclast Precursors and Indirectly via Osteoblast Lineage Cells J. Biol. Chem., March 7, 2008; 283(10): 6509 - 6518. [Abstract] [Full Text] [PDF]

				S. Tagami, M. Okochi, K. Yanagida, A. Ikuta, A. Fukumori, N. Matsumoto, Y. Ishizuka-Katsura, T. Nakayama, N. Itoh, J. Jiang, et al. Regulation of Notch Signaling by Dynamic Changes in the Precision of S3 Cleavage of Notch-1 Mol. Cell. Biol., January 1, 2008; 28(1): 165 - 176. [Abstract] [Full Text] [PDF]

				U.-M. Fiuza and A. M. Arias Cell and molecular biology of Notch J. Endocrinol., September 1, 2007; 194(3): 459 - 474. [Abstract] [Full Text] [PDF]

				V. Bolos, J. Grego-Bessa, and J. L. de la Pompa Notch Signaling in Development and Cancer Endocr. Rev., May 1, 2007; 28(3): 339 - 363. [Abstract] [Full Text] [PDF]

				X. Song, G. B. Call, D. Kirilly, and T. Xie Notch signaling controls germline stem cell niche formation in the Drosophila ovary Development, March 15, 2007; 134(6): 1071 - 1080. [Abstract] [Full Text] [PDF]

				I. Rubio-Aliaga, D. Soewarto, S. Wagner, M. Klaften, H. Fuchs, S. Kalaydjiev, D. H. Busch, M. Klempt, B. Rathkolb, E. Wolf, et al. A Genetic Screen for Modifiers of the Delta1-Dependent Notch Signaling Function in the Mouse Genetics, March 1, 2007; 175(3): 1451 - 1463. [Abstract] [Full Text] [PDF]

				S. H. Eun, K. Lea, E. Overstreet, S. Stevens, J.-H. Lee, and J. A. Fischer Identification of Genes That Interact With Drosophila liquid facets Genetics, March 1, 2007; 175(3): 1163 - 1174. [Abstract] [Full Text] [PDF]

				J. T. Nichols, A. Miyamoto, S. L. Olsen, B. D'Souza, C. Yao, and G. Weinmaster DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur J. Cell Biol., February 12, 2007; 176(4): 445 - 458. [Abstract] [Full Text] [PDF]

				N. Sasaki, T. Sasamura, H. O. Ishikawa, M. Kanai, R. Ueda, K. Saigo, and K. Matsuno Polarized exocytosis and transcytosis of Notch during its apical localization in Drosophila epithelial cells. Genes Cells, January 1, 2007; 12(1): 89 - 103. [Abstract] [Full Text] [PDF]

				C. Commisso and G. L. Boulianne The NHR1 Domain of Neuralized Binds Delta and Mediates Delta Trafficking and Notch Signaling Mol. Biol. Cell, January 1, 2007; 18(1): 1 - 13. [Abstract] [Full Text] [PDF]

				A. L. Parks, J. R. Stout, S. B. Shepard, K. M. Klueg, A. A. Dos Santos, T. R. Parody, M. Vaskova, and M. A. T. Muskavitch Structure-Function Analysis of Delta Trafficking, Receptor Binding and Signaling in Drosophila Genetics, December 1, 2006; 174(4): 1947 - 1961. [Abstract] [Full Text] [PDF]

				R. Song, B.-K. Koo, K.-J. Yoon, M.-J. Yoon, K.-W. Yoo, H.-T. Kim, H.-J. Oh, Y.-Y. Kim, J.-K. Han, C.-H. Kim, et al. Neuralized-2 Regulates a Notch Ligand in Cooperation with Mind Bomb-1 J. Biol. Chem., November 24, 2006; 281(47): 36391 - 36400. [Abstract] [Full Text] [PDF]

				M. J. Malecki, C. Sanchez-Irizarry, J. L. Mitchell, G. Histen, M. L. Xu, J. C. Aster, and S. C. Blacklow Leukemia-Associated Mutations within the NOTCH1 Heterodimerization Domain Fall into at Least Two Distinct Mechanistic Classes Mol. Cell. Biol., June 15, 2006; 26(12): 4642 - 4651. [Abstract] [Full Text] [PDF]

				E. J. Hagedorn, J. L. Bayraktar, V. R. Kandachar, T. Bai, D. M. Englert, and H. C. Chang Drosophila melanogaster auxilin regulates the internalization of Delta to control activity of the Notch signaling pathway J. Cell Biol., May 8, 2006; 173(3): 443 - 452. [Abstract] [Full Text] [PDF]

				M. B. Mahoney, A. L. Parks, D. A. Ruddy, S. Y. K. Tiong, H. Esengil, A. C. Phan, P. Philandrinos, C. G. Winter, R. Chatterjee, K. Huppert, et al. Presenilin-Based Genetic Screens in Drosophila melanogaster Identify Novel Notch Pathway Modifiers Genetics, April 1, 2006; 172(4): 2309 - 2324. [Abstract] [Full Text] [PDF]

				K. G. Leong and A. Karsan Recent insights into the role of Notch signaling in tumorigenesis Blood, March 15, 2006; 107(6): 2223 - 2233. [Abstract] [Full Text] [PDF]

				L. Miele Notch Signaling Clin. Cancer Res., February 15, 2006; 12(4): 1074 - 1079. [Full Text] [PDF]

				B.-K. Koo, H.-S. Lim, R. Song, M.-J. Yoon, K.-J. Yoon, J.-S. Moon, Y.-W. Kim, M.-c. Kwon, K.-W. Yoo, M.-P. Kong, et al. Mind bomb 1 is essential for generating functional Notch ligands to activate Notch Development, August 1, 2005; 132(15): 3459 - 3470. [Abstract] [Full Text] [PDF]

				E. Mizuhara, T. Nakatani, Y. Minaki, Y. Sakamoto, Y. Ono, and Y. Takai MAGI1 Recruits Dll1 to Cadherin-based Adherens Junctions and Stabilizes It on the Cell Surface J. Biol. Chem., July 15, 2005; 280(28): 26499 - 26507. [Abstract] [Full Text] [PDF]

				W. Wang and G. Struhl Distinct roles for Mind bomb, Neuralized and Epsin in mediating DSL endocytosis and signaling in Drosophila Development, June 15, 2005; 132(12): 2883 - 2894. [Abstract] [Full Text] [PDF]

				E. C. Lai, F. Roegiers, X. Qin, Y. N. Jan, and G. M. Rubin The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta Development, May 15, 2005; 132(10): 2319 - 2332. [Abstract] [Full Text] [PDF]

				R. Le Borgne, A. Bardin, and F. Schweisguth The roles of receptor and ligand endocytosis in regulating Notch signaling Development, April 15, 2005; 132(8): 1751 - 1762. [Abstract] [Full Text] [PDF]

				L.-T. Yang, J. T. Nichols, C. Yao, J. O. Manilay, E. A. Robey, and G. Weinmaster Fringe Glycosyltransferases Differentially Modulate Notch1 Proteolysis Induced by Delta1 and Jagged1 Mol. Biol. Cell, February 1, 2005; 16(2): 927 - 942. [Abstract] [Full Text] [PDF]

				A. Sapir, E. Assa-Kunik, R. Tsruya, E. Schejter, and B.-Z. Shilo Unidirectional Notch signaling depends on continuous cleavage of Delta Development, January 1, 2005; 132(1): 123 - 132. [Abstract] [Full Text] [PDF]

				F. Ahimou, L.-P. Mok, B. Bardot, and C. Wesley The adhesion force of Notch with Delta and the rate of Notch signaling J. Cell Biol., December 20, 2004; 167(6): 1217 - 1229. [Abstract] [Full Text] [PDF]

				M. Vooijs, E. H. Schroeter, Y. Pan, M. Blandford, and R. Kopan Ectodomain Shedding and Intramembrane Cleavage of Mammalian Notch Proteins Are Not Regulated through Oligomerization J. Biol. Chem., December 3, 2004; 279(49): 50864 - 50873. [Abstract] [Full Text] [PDF]

				X. Tian, D. Hansen, T. Schedl, and J. B. Skeath Epsin potentiates Notch pathway activity in Drosophila and C. elegans Development, December 1, 2004; 131(23): 5807 - 5815. [Abstract] [Full Text] [PDF]