Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation

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[Abstract] [Full Text] [PDF]

S. R. Browd, A. M. Kenney, O. N. Gottfried, J. W. Yoon, D. Walterhouse, C. A. Pedone, and D. W. Fults
N-myc Can Substitute for Insulin-Like Growth Factor Signaling in a Mouse Model of Sonic Hedgehog-Induced Medulloblastoma.
Cancer Res., March 1, 2006; 66(5): 2666 - 2672.
[Abstract] [Full Text] [PDF]

K. Saha and D. V. Schaffer
Signal dynamics in Sonic hedgehog tissue patterning
Development, March 1, 2006; 133(5): 889 - 900.
[Abstract] [Full Text] [PDF]

M. C. Hu, R. Mo, S. Bhella, C. W. Wilson, P.-T. Chuang, C.-c. Hui, and N. D. Rosenblum
GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis
Development, February 1, 2006; 133(3): 569 - 578.
[Abstract] [Full Text] [PDF]

L. Koziel, M. Wuelling, S. Schneider, and A. Vortkamp
Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation
Development, December 1, 2005; 132(23): 5249 - 5260.
[Abstract] [Full Text] [PDF]

M. J. Hilton, X. Tu, J. Cook, H. Hu, and F. Long
Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development
Development, October 1, 2005; 132(19): 4339 - 4351.
[Abstract] [Full Text] [PDF]

M.-H. Chen, N. Gao, T. Kawakami, and P.-T. Chuang
Mice Deficient in the Fused Homolog Do Not Exhibit Phenotypes Indicative of Perturbed Hedgehog Signaling during Embryonic Development
Mol. Cell. Biol., August 15, 2005; 25(16): 7042 - 7053.
[Abstract] [Full Text] [PDF]

M. Merchant, M. Evangelista, S.-M. Luoh, G. D. Frantz, S. Chalasani, R. A. D. Carano, M. van Hoy, J. Ramirez, A. K. Ogasawara, L. M. McFarland, et al.
Loss of the Serine/Threonine Kinase Fused Results in Postnatal Growth Defects and Lethality Due to Progressive Hydrocephalus
Mol. Cell. Biol., August 15, 2005; 25(16): 7054 - 7068.
[Abstract] [Full Text] [PDF]

A. L. Hager-Theodorides, J. T. Dessens, S. V. Outram, and T. Crompton
The transcription factor Gli3 regulates differentiation of fetal CD4-CD8- double-negative thymocytes
Blood, August 15, 2005; 106(4): 1296 - 1304.
[Abstract] [Full Text] [PDF]

V. Nguyen, A. L. Chokas, B. Stecca, and A. R. i Altaba
Cooperative requirement of the Gli proteins in neurogenesis
Development, July 15, 2005; 132(14): 3267 - 3279.
[Abstract] [Full Text] [PDF]

V. Stepan, S. Ramamoorthy, H. Nitsche, Y. Zavros, J. L. Merchant, and A. Todisco
Regulation and Function of the Sonic Hedgehog Signal Transduction Pathway in Isolated Gastric Parietal Cells
J. Biol. Chem., April 22, 2005; 280(16): 15700 - 15708.
[Abstract] [Full Text] [PDF]

D. Stamataki, F. Ulloa, S. V. Tsoni, A. Mynett, and J. Briscoe
A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube
Genes & Dev., March 1, 2005; 19(5): 626 - 641.
[Abstract] [Full Text] [PDF]

A. McDermott, M. Gustafsson, T. Elsam, C.-C. Hui, C. P. Emerson Jr, and A.-G. Borycki
Gli2 and Gli3 have redundant and context-dependent function in skeletal muscle formation
Development, January 15, 2005; 132(2): 345 - 357.
[Abstract] [Full Text] [PDF]

R. Zeller
It Takes Time to Make a Pinky: Unexpected Insights into How SHH Patterns Vertebrate Digits
Sci. Signal., November 16, 2004; 2004(259): pe53 - pe53.
[Abstract] [Full Text] [PDF]

J. D. Corrales, G. L. Rocco, S. Blaess, Q. Guo, and A. L. Joyner
Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development
Development, November 15, 2004; 131(22): 5581 - 5590.
[Abstract] [Full Text] [PDF]

A. Brancaccio, A. Minichiello, M. Grachtchouk, D. Antonini, H. Sheng, R. Parlato, N. Dathan, A. A. Dlugosz, and C. Missero
Requirement of the forkhead gene Foxe1, a target of sonic hedgehog signaling, in hair follicle morphogenesis
Hum. Mol. Genet., November 1, 2004; 13(21): 2595 - 2606.
[Abstract] [Full Text] [PDF]

M. Fuccillo, M. Rallu, A. P. McMahon, and G. Fishell
Temporal requirement for hedgehog signaling in ventral telencephalic patterning
Development, October 15, 2004; 131(20): 5031 - 5040.
[Abstract] [Full Text] [PDF]

				E. Dessaud, A. P. McMahon, and J. Briscoe Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network Development, August 1, 2008; 135(15): 2489 - 2503. [Abstract] [Full Text] [PDF]

				J. B. Regard and Y. Yang Hedgehog Signaling in Postnatal Bone IBMS BoneKEy, July 1, 2008; 5(7): 243 - 252. [Abstract] [Full Text] [PDF]

				T. Eichberger, A. Kaser, C. Pixner, C. Schmid, S. Klingler, M. Winklmayr, C. Hauser-Kronberger, F. Aberger, and A.-M. Frischauf GLI2-specific Transcriptional Activation of the Bone Morphogenetic Protein/Activin Antagonist Follistatin in Human Epidermal Cells J. Biol. Chem., May 2, 2008; 283(18): 12426 - 12437. [Abstract] [Full Text] [PDF]

				K. E. Galvin, H. Ye, D. J. Erstad, R. Feddersen, and C. Wetmore Gli1 Induces G2/M Arrest and Apoptosis in Hippocampal but Not Tumor-Derived Neural Stem Cells Stem Cells, April 1, 2008; 26(4): 1027 - 1036. [Abstract] [Full Text] [PDF]

				K. R. Badri, Y. Zhou, and L. Schuger Embryological Origin of Airway Smooth Muscle Proceedings of the ATS, January 1, 2008; 5(1): 4 - 10. [Abstract] [Full Text] [PDF]

				M. Fiaschi, B. Rozell, A. Bergstrom, R. Toftgard, and M. I. Kleman Targeted Expression of GLI1 in the Mammary Gland Disrupts Pregnancy-induced Maturation and Causes Lactation Failure J. Biol. Chem., December 7, 2007; 282(49): 36090 - 36101. [Abstract] [Full Text] [PDF]

				S. Thiyagarajan, N. Bhatia, S. Reagan-Shaw, D. Cozma, A. Thomas-Tikhonenko, N. Ahmad, and V. S. Spiegelman Role of GLI2 Transcription Factor in Growth and Tumorigenicity of Prostate Cells Cancer Res., November 15, 2007; 67(22): 10642 - 10646. [Abstract] [Full Text] [PDF]

				M. Fernandes, G. Gutin, H. Alcorn, S. K. McConnell, and J. M. Hebert Mutations in the BMP pathway in mice support the existence of two molecular classes of holoprosencephaly Development, November 1, 2007; 134(21): 3789 - 3794. [Abstract] [Full Text] [PDF]

				G. R. van den Brink Hedgehog Signaling in Development and Homeostasis of the Gastrointestinal Tract Physiol Rev, October 1, 2007; 87(4): 1343 - 1375. [Abstract] [Full Text] [PDF]

				V. L. Ruiz-Perez, H. J. Blair, M. E. Rodriguez-Andres, M. J. Blanco, A. Wilson, Y.-N. Liu, C. Miles, H. Peters, and J. A. Goodship Evc is a positive mediator of Ihh-regulated bone growth that localises at the base of chondrocyte cilia Development, August 15, 2007; 134(16): 2903 - 2912. [Abstract] [Full Text] [PDF]

				X. Zhu, A. S. Gleiberman, and M. G. Rosenfeld Molecular Physiology of Pituitary Development: Signaling and Transcriptional Networks Physiol Rev, July 1, 2007; 87(3): 933 - 963. [Abstract] [Full Text] [PDF]

				J. Bok, D. K. Dolson, P. Hill, U. Ruther, D. J. Epstein, and D. K. Wu Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear Development, May 1, 2007; 134(9): 1713 - 1722. [Abstract] [Full Text] [PDF]

				N. J. Rowbotham, A. L. Hager-Theodorides, M. Cebecauer, D. K. Shah, E. Drakopoulou, J. Dyson, S. V. Outram, and T. Crompton Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activation Blood, May 1, 2007; 109(9): 3757 - 3766. [Abstract] [Full Text] [PDF]

				Y. Kim, J. W. Yoon, X. Xiao, N. M. Dean, B. P. Monia, and E. G. Marcusson Selective Down-Regulation of Glioma-Associated Oncogene 2 Inhibits the Proliferation of Hepatocellular Carcinoma Cells Cancer Res., April 15, 2007; 67(8): 3583 - 3593. [Abstract] [Full Text] [PDF]

				R. Haraguchi, J. Motoyama, H. Sasaki, Y. Satoh, S. Miyagawa, N. Nakagata, A. Moon, and G. Yamada Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling Development, February 1, 2007; 134(3): 525 - 533. [Abstract] [Full Text] [PDF]

				C. J. Haycraft, Q. Zhang, B. Song, W. S. Jackson, P. J. Detloff, R. Serra, and B. K. Yoder Intraflagellar transport is essential for endochondral bone formation Development, January 15, 2007; 134(2): 307 - 316. [Abstract] [Full Text] [PDF]

				Y. Maeda, V. Dave, and J. A. Whitsett Transcriptional Control of Lung Morphogenesis Physiol Rev, January 1, 2007; 87(1): 219 - 244. [Abstract] [Full Text] [PDF]

				H. Zhou, S. Kim, S. Ishii, and T. G. Boyer Mediator Modulates Gli3-Dependent Sonic Hedgehog Signaling Mol. Cell. Biol., December 1, 2006; 26(23): 8667 - 8682. [Abstract] [Full Text] [PDF]

				I. Sarkaria, P. O-charoenrat, S. G. Talbot, P. G. Reddy, I. Ngai, E. Maghami, K. N. Patel, B. Lee, Y. Yonekawa, M. Dudas, et al. Squamous Cell Carcinoma Related Oncogene/DCUN1D1 Is Highly Conserved and Activated by Amplification in Squamous Cell Carcinomas Cancer Res., October 1, 2006; 66(19): 9437 - 9444. [Abstract] [Full Text] [PDF]

				J. Xu, B. P. Srinivas, S. Y. Tay, A. Mak, X. Yu, S. G. P. Lee, H. Yang, K. R. Govindarajan, B. Leong, G. Bourque, et al. Genomewide Expression Profiling in the Zebrafish Embryo Identifies Target Genes Regulated by Hedgehog Signaling During Vertebrate Development Genetics, October 1, 2006; 174(2): 735 - 752. [Abstract] [Full Text] [PDF]

				S. J. Hatsell and P. Cowin Gli3-mediated repression of Hedgehog targets is required for normal mammary development Development, September 15, 2006; 133(18): 3661 - 3670. [Abstract] [Full Text] [PDF]

				M. Grachtchouk, J. Liu, A. Wang, L. Wei, C. K. Bichakjian, J. Garlick, A. F. Paulino, T. Giordano, and A. A. Dlugosz Odontogenic Keratocysts Arise from Quiescent Epithelial Rests and Are Associated with Deregulated Hedgehog Signaling in Mice and Humans Am. J. Pathol., September 1, 2006; 169(3): 806 - 814. [Abstract] [Full Text] [PDF]

				M. Kasper, H. Schnidar, G. W. Neill, M. Hanneder, S. Klingler, L. Blaas, C. Schmid, C. Hauser-Kronberger, G. Regl, M. P. Philpott, et al. Selective Modulation of Hedgehog/GLI Target Gene Expression by Epidermal Growth Factor Signaling in Human Keratinocytes. Mol. Cell. Biol., August 1, 2006; 26(16): 6283 - 6298. [Abstract] [Full Text] [PDF]

				J. A. Sterling, B. O. Oyajobi, B. Grubbs, S. S. Padalecki, S. A. Munoz, A. Gupta, B. Story, M. Zhao, and G. R. Mundy The hedgehog signaling molecule gli2 induces parathyroid hormone-related Peptide expression and osteolysis in metastatic human breast cancer cells. Cancer Res., August 1, 2006; 66(15): 7548 - 7553. [Abstract] [Full Text] [PDF]

				G R van den Brink and J C H Hardwick Hedgehog Wnteraction in colorectal cancer Gut, July 1, 2006; 55(7): 912 - 914. [Full Text] [PDF]

				Y. Pan, C. B. Bai, A. L. Joyner, and B. Wang Sonic hedgehog Signaling Regulates Gli2 Transcriptional Activity by Suppressing Its Processing and Degradation. Mol. Cell. Biol., May 1, 2006; 26(9): 3365 - 3377. [Abstract] [Full Text] [PDF]

				S. Blaess, J. D. Corrales, and A. L. Joyner Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region Development, May 1, 2006; 133(9): 1799 - 1809. [Abstract] [Full Text] [PDF]

				J. D. Corrales, S. Blaess, E. M. Mahoney, and A. L. Joyner The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation Development, May 1, 2006; 133(9): 1811 - 1821. [Abstract] [Full Text] [PDF]

				M. van Tuyl, J. Liu, F. Groenman, R. Ridsdale, R. N. N. Han, V. Venkatesh, D. Tibboel, and M. Post Iroquois genes influence proximo-distal morphogenesis during rat lung development Am J Physiol Lung Cell Mol Physiol, April 1, 2006; 290(4): L777 - L789. [Abstract] [Full Text] [PDF]

				S. R. Browd, A. M. Kenney, O. N. Gottfried, J. W. Yoon, D. Walterhouse, C. A. Pedone, and D. W. Fults N-myc Can Substitute for Insulin-Like Growth Factor Signaling in a Mouse Model of Sonic Hedgehog-Induced Medulloblastoma. Cancer Res., March 1, 2006; 66(5): 2666 - 2672. [Abstract] [Full Text] [PDF]