The Drosophila homeobox gene optix is capable of inducing ectopic eyes by an eyeless-independent mechanism

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Seimiya, M.
	Articles by Gehring, W. J.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Seimiya, M.
	Articles by Gehring, W. J.

Bonini, N. M., Leiserson, W. M. and Benzer, S (1993). The eyes absent gene: Genetic control of cell survival and differentiation in the developing Drosophila eye. Cell 72, 379-395.[Medline]

Bonini, N. M., Bui, Q. T., Gray-Board, G. L. and Warrick, J. M (1997). The Drosophilaeyes absent gene directs ectopic eye formation in a pathway conserved between flies and vertebrates. Development 124, 4819-4826.[Abstract]

Boucher, C. A., King, S. K., Carey, N., Krahe, R., Winchester, C. L., Rahman, S., Creavin, T., Meghji, P., Bailey, M. E., Chartier, F. L., et al (1995). A novel homeodomain-encoding gene is associated with a large CpG island interrupted by the myotonic dystrophy unstable (CTG)n repeat. Hum. Mol. Genet 4, 1919-1925.[Abstract/Free Full Text]

Boucher, C. A., Carey, N., Edwards, Y. H., Siciliano, M. J. and Johnson, K. J (1996). Cloning of the human SIX1 gene and its assignment to chromosome 14. Genomics 33, 140-142.[Medline]

Bovolenta, P., Mallamaci, A. and Boncinelli, E (1996). Cloning and characterization of two chick homeobox genes, members of the Six / sine oculis family, expressed during eye development. Int. J. Dev. Biol 1, 73-74.

Bovolenta, P., Mallamaci, A., Puelles, L. and Boncinelli, E (1998). Expression pattern of cSix3 , a member of the Six/sine oculis family of transcription factors. Mech. Dev 70, 201-203.[Medline]

Brand, A. H. and Perrimon, N (1993). Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401-415.[Abstract]

Callaerts, P., Halder, G. and Gehring, W. J (1997). Pax-6 in development and evolution. Ann. Rev. Neurosci 20, 483-532.[Medline]

Chen, R., Amoui, M., Zhang, Z. and Mardon, G (1997). Dachshund andEyes absent proteins form a complex and function synergistically to induce ectopic eye development in Drosophila. Cell 92, 893-903.

Cheyette, B. N. R., Green, P. J., Martin, K., Garren, H., Hartenstein, V. and Zipursky, S. L (1994). The Drosophilasine oculis locus encodes a homeodomain-containing protein required for the development of the entire visual system. Neuron 12, 977-996.[Medline]

Granadino, B., Gallardo, M. E., Lopez-R\222os, J., Sanz, R., Ramos, C., Ayuso, C., Bovolenta, P. and Rodr\222guez de Cordoba, S (1999). Genomic cloning, structure, exp chromosomal location of the human SIX3 gene. Genomics 55, 100-105.[Medline]

Halder, G., Callaerts, P. and Gehring, W. J (1995). Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila. Science 267, 1788-1792.[Abstract/Free Full Text]

Halder, G., Callaerts, P., Filster, S., Walldorf, U., Kloter, U. and Gehring, W. J (1998). Eyeless initiates the expression of both sine oculis and eyes absent during Drosophila compound eye development. Development 125, 2181-2191.[Abstract]

Jean, D., Bernier, G. and Gruss, P (1999). Six6 (Optx2) is a novel murine Six3-related homeobox gene that demarcates the presumptive pituitary/hypothalamic axis and the ventral optic stalk. Mech. Dev 84, 31-40.[Medline]

Kawakami, K., Ohto, H., Ikeda, K. and Roeder, R. G (1996). Structure, function and expression of a murine homeobox protein AREC3, a homologue of Drosophila sine oculis gene product, and implication in development. Nucleic Acids Res 24, 303-310.[Abstract/Free Full Text]

Kawakami, K., Ohto, H., Takizawa, T. and Sito, T (1996). Identification and expression of six family genes in mouse retina. FEBS Lett 393, 259-263.[Medline]

Kobayashi, M., Toyama, R., Takeda, H., Dawid, I. B. and Kawakami, K (1998). Overexpression of the forebrain-specific homeobox gene six3 induces rostral forebrain enlargement in zebrafish. Development 125, 2973-2982.[Abstract]

Loosli, F., K\232ster, R. W., Carl, M., Krone, A. and Wittbrodt, J (1998). Six3 , a medaka homologue of the Drosophila homeobox gene sine oculis is expressed in the anterior embryonic shield and the developing eye. Mech. Dev 74, 159-164.[Medline]

Loosli, F., Winkler, S. and Wittbrodt, J (1999). Six3 overexpression initiates the formation of ectopic retina. Genes Dev 13, 649-654.[Abstract/Free Full Text]

Maroto, M., Reshef, R., Munsterberg, A. E., Koester, S., Goulding, M. and Lassar, A. B (1997). Ectopic Pax-3 activates MyoD and Myf-5 expression in embryonic mesoderm and neural tissue. Cell 89, 139-148.[Medline]

Niimi, T., Seimiya, M., Kloter, U., Flister, S. and Ghering, W. J (1999). Direct regulatory interaction of the eyeless protein with an eye-specific enhancer in the sine oculis gene during eye induction in Drosophila. Development 126, 2253-2260.[Abstract]

Niiya, A., Ohto, H., Kawakami, K. and Araki, M (1998). Localization of Six4 /AREC3 in the developing mouse retina; implications in mammalian retinal development. Exp. Eye Res 67, 699-707.[Medline]

Ohto, H., Kamada, S., Tago, K., Tominaga, S., Ozaki, H., Sato, S. and Kawakami, K (1999). Cooperation of Six and Eya in activation of their Target genes through nuclear translocation of Eya. Mol. Cell. Biol 10, 6815-6824.

Oliver, G., Mailhos, A., Wehr, R., Copeland, N. G., Jenkins, N. A. and Gruss, P (1995). Six3 , a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development. Development 121, 4045-4055.[Abstract]

Oliver, G., Wehr, R., Jenkins, N. A., Copeland, N. G., Cheyette, B. N. R., Hartenstein, V., Zipursky, S. L. and Gruss, P (1995). Homeobox genes and connective tissue patterning. Development 121, 693-705.[Abstract]

Oliver, G., Loosli, F., K\232ster, R., Wittbrodt, J. and Gruss, P (1996). Ectopic lens induction in fish in response to the murine homeobox gene Six3. Mech. Dev 60, 233-239.[Medline]

Pignoni, F., Hu, B., Zavitz, K. H., Xiao, J., Garrity, P. A. and Zipursky, S. L (1997). The eye-specification proteins So and Eya form a complex and regulate multiple steps in Drosophila eye development. Cell 91, 881-891.[Medline]

Quiring, R., Walldorf, U., Kloter, U. and Gehring, W. J (1994). Homology of the eyeless gene of Drosophila to the Small eye gene in mice and Aniridia in humans. Science 265, 785-789.[Abstract/Free Full Text]

Rubin, G. M. and Spradling, A. C (1982). Genetic transformation of Drosophila with transposable element vectors. Science 218, 348-353.[Abstract/Free Full Text]

Seo H. C., Drivenes, \257., Ellingsen, S. and Fjose, A (1998). Expression of two zebrafish homologues of the murine Six3 gene demarcates the initial eye primordia. Mech. Dev 73, 45-57.[Medline]

Seo H. C., Drivenes, \257., Ellingsen, S. and Fjose, A (1998). Transient expression of a novel Six3-related zebrafish gene during gastrulation and eye formation. Gene 216, 39-46.[Medline]

Seo H. C., Drivenes, \257. and Fjose, A (1998). A zebrafish Six4 homologue with early expression in head mesoderm. Biochim. Biophys. Acta 1442, 427-431.[Medline]

Seo H. C., Curtiss, J., Mlodzik, M. and Fjose, A (1999). Six class homeobox genes in Drosophila belong to three distinct families and are involved in head development. Mech. Dev 83, 127-139.[Medline]

Serikaku, M. A. and O'Tousa, J. E (1994). sine oculis is a homeobox gene required for Drosohpila visual system development. Genetics 138, 1137-1150.[Abstract]

Shen, W. and Mardon, G (1997). Ectopic eye development in Drosophila induced by directed dachshund expression. Development 124, 45-52.[Abstract]

Staehling-Hampton, K., Jackson, P. D., Clark, M. J., Brand, A. H. and Hoffmann, F. M (1994). Specificity of bone morphogenetic protein-related factors: cell fate and gene expression changes in Drosophila embryos induced by decapentaplegic but not 60A. Cell Growth Diff 5, 585-593.[Abstract]

Tajbakhsh, S., Rocancourt, D., Cossu, G. and Buckingham, M (1997). Redefining the genetic hierarchies controlling skeletal myogenesis: Pax-3 and Myf-5 act upstream of MyoD. Cell 89, 127-138.[Medline]

Toy, J., Yang, J. M., Leppert, G. S. and Sundin, O. H (1998). The Optx2 homeobox gene is expressed in early precursors of the eye and activates retina-specific genes. Proc. Natl. Acad. Sci. USA 95, 10643-10648.[Abstract/Free Full Text]

Winchester, C. L., Ferrier, R. K., Sermoni, A., Clark,B. J. and Johnson, K. J (1999). Characterization of the expression of DMPK and SIX5 in the human eye and implications for pathogenesis in myotonic dystrophy. Hum. Mol. Genet 8, 481-492.[Abstract/Free Full Text]

Xu, P., Cheng, J., Epstein, J. and Maas, R. L (1997). Mouse Eya genes are expressed during limb tendon development and encode a transcriptional activation function. Proc. Natl. Acad. Sci. USA 94, 11974-11979.[Abstract/Free Full Text]

Zuber, M. E., Perron, M., Philpott, A., Bang, A. and Harris, W. A (1999). Giant eyes in Xenopus laevis by overexpression of Xoptx2. Cell 98, 341-352.[Medline]

This article has been cited by other articles:

I. Appolloni, F. Calzolari, G. Corte, R. Perris, and P. Malatesta
Six3 Controls the Neural Progenitor Status in the Murine CNS
Cereb Cortex, March 1, 2008; 18(3): 553 - 562.
[Abstract] [Full Text] [PDF]

D. Coiffier, B. Charroux, and S. Kerridge
Common functions of central and posterior Hox genes for the repression of head in the trunk of Drosophila
Development, January 15, 2008; 135(2): 291 - 300.
[Abstract] [Full Text] [PDF]

E. J. Ostrin, Y. Li, K. Hoffman, J. Liu, K. Wang, L. Zhang, G. Mardon, and R. Chen
Genome-wide identification of direct targets of the Drosophila retinal determination protein Eyeless
Genome Res., April 1, 2006; 16(4): 466 - 476.
[Abstract] [Full Text] [PDF]

J. Bessa and F. Casares
Restricted teashirt expression confers eye-specific responsiveness to Dpp and Wg signals during eye specification in Drosophila
Development, November 15, 2005; 132(22): 5011 - 5020.
[Abstract] [Full Text] [PDF]

S. J. Silver and I. Rebay
Signaling circuitries in development: insights from the retinal determination gene network
Development, January 1, 2005; 132(1): 3 - 13.
[Abstract] [Full Text] [PDF]

S. Aijaz, B. J. Clark, K. Williamson, V. van Heyningen, D. Morrison, D. FitzPatrick, R. Collin, N. Ragge, A. Christoforou, A. Brown, et al.
Absence of SIX6 Mutations in Microphthalmia, Anophthalmia, and Coloboma
Invest. Ophthalmol. Vis. Sci., November 1, 2004; 45(11): 3871 - 3876.
[Abstract] [Full Text] [PDF]

J. P. Kumar, T. Jamal, A. Doetsch, F. R. Turner, and J. B. Duffy
CREB Binding Protein Functions During Successive Stages of Eye Development in Drosophila
Genetics, October 1, 2004; 168(2): 877 - 893.
[Abstract] [Full Text] [PDF]

J. K. Inlow and L. L. Restifo
Molecular and Comparative Genetics of Mental Retardation
Genetics, February 1, 2004; 166(2): 835 - 881.
[Abstract] [Full Text] [PDF]

F. Janody, J. D. Lee, N. Jahren, D. J. Hazelett, A. Benlali, G. I. Miura, I. Draskovic, and J. E. Treisman
A Mosaic Genetic Screen Reveals Distinct Roles for trithorax and Polycomb Group Genes in Drosophila Eye Development
Genetics, January 1, 2004; 166(1): 187 - 200.
[Abstract] [Full Text] [PDF]

M. E. Zuber, G. Gestri, A. S. Viczian, G. Barsacchi, and W. A. Harris
Specification of the vertebrate eye by a network of eye field transcription factors
Development, November 1, 2003; 130(21): 5155 - 5167.
[Abstract] [Full Text] [PDF]

C.-C. Jang, J.-L. Chao, N. Jones, L.-C. Yao, D. A. Bessarab, Y. M. Kuo, S. Jun, C. Desplan, S. K. Beckendorf, and Y. H. Sun
Two Pax genes, eye gone and eyeless, act cooperatively in promoting Drosophila eye development
Development, July 1, 2003; 130(13): 2939 - 2951.
[Abstract] [Full Text] [PDF]

L. Michaut, S. Flister, M. Neeb, K. P. White, U. Certa, and W. J. Gehring
Analysis of the eye developmental pathway in Drosophila using DNA microarrays
PNAS, April 1, 2003; 100(7): 4024 - 4029.
[Abstract] [Full Text] [PDF]

C. C. Zhu, M. A. Dyer, M. Uchikawa, H. Kondoh, O. V. Lagutin, and G. Oliver
Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors
Development, March 8, 2003; 129(12): 2835 - 2849.
[Abstract] [Full Text] [PDF]

J. Kronhamn, E. Frei, M. Daube, R. Jiao, Y. Shi, M. Noll, and A. Rasmuson-Lestander
Headless flies produced by mutations in the paralogous Pax6 genes eyeless and twin of eyeless
Development, March 4, 2003; 129(4): 1015 - 1026.
[Abstract] [Full Text] [PDF]

J. Lopez-Rios, K. Tessmar, F. Loosli, J. Wittbrodt, and P. Bovolenta
Six3 and Six6 activity is modulated by members of the groucho family
Development, January 1, 2003; 130(1): 185 - 195.
[Abstract] [Full Text] [PDF]

G. Goudreau, P. Petrou, L. W. Reneker, J. Graw, J. Loster, and P. Gruss
Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype
PNAS, June 25, 2002; 99(13): 8719 - 8724.
[Abstract] [Full Text] [PDF]

D. Arendt, K. Tessmar, M.-I. M. de Campos-Baptista, A. Dorresteijn, and J. Wittbrodt
Development of pigment-cup eyes in the polychaete Platynereis dumerilii and evolutionary conservation of larval eyes in Bilateria
Development, January 3, 2002; 129(5): 1143 - 1154.
[Abstract] [Full Text] [PDF]

F. Loosli, S. Winkler, C. Burgtorf, E. Wurmbach, W. Ansorge, T. Henrich, C. Grabher, D. Arendt, M. Carl, A. Krone, et al.
Medaka eyeless is the key factor linking retinal determination and eye growth
Development, October 15, 2001; 128(20): 4035 - 4044.
[Abstract] [Full Text] [PDF]

J Treisman
Drosophila homologues of the transcriptional coactivation complex subunits TRAP240 and TRAP230 are required for identical processes in eye-antennal disc development
Development, January 2, 2001; 128(4): 603 - 615.
[Abstract] [PDF]

Y. Onuma, S. Takahashi, M. Asashima, S. Kurata, and W. J. Gehring
Conservation of Pax 6 function and upstream activation by Notch signaling in eye development of frogs and flies
PNAS, February 19, 2002; 99(4): 2020 - 2025.
[Abstract] [Full Text] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Seimiya, M.

Articles by Gehring, W. J.

Search for Related Content

PubMed

PubMed Citation

Articles by Seimiya, M.

Articles by Gehring, W. J.

				D. Coiffier, B. Charroux, and S. Kerridge Common functions of central and posterior Hox genes for the repression of head in the trunk of Drosophila Development, January 15, 2008; 135(2): 291 - 300. [Abstract] [Full Text] [PDF]

				E. J. Ostrin, Y. Li, K. Hoffman, J. Liu, K. Wang, L. Zhang, G. Mardon, and R. Chen Genome-wide identification of direct targets of the Drosophila retinal determination protein Eyeless Genome Res., April 1, 2006; 16(4): 466 - 476. [Abstract] [Full Text] [PDF]

				J. Bessa and F. Casares Restricted teashirt expression confers eye-specific responsiveness to Dpp and Wg signals during eye specification in Drosophila Development, November 15, 2005; 132(22): 5011 - 5020. [Abstract] [Full Text] [PDF]

				S. J. Silver and I. Rebay Signaling circuitries in development: insights from the retinal determination gene network Development, January 1, 2005; 132(1): 3 - 13. [Abstract] [Full Text] [PDF]

				S. Aijaz, B. J. Clark, K. Williamson, V. van Heyningen, D. Morrison, D. FitzPatrick, R. Collin, N. Ragge, A. Christoforou, A. Brown, et al. Absence of SIX6 Mutations in Microphthalmia, Anophthalmia, and Coloboma Invest. Ophthalmol. Vis. Sci., November 1, 2004; 45(11): 3871 - 3876. [Abstract] [Full Text] [PDF]

				J. P. Kumar, T. Jamal, A. Doetsch, F. R. Turner, and J. B. Duffy CREB Binding Protein Functions During Successive Stages of Eye Development in Drosophila Genetics, October 1, 2004; 168(2): 877 - 893. [Abstract] [Full Text] [PDF]

				J. K. Inlow and L. L. Restifo Molecular and Comparative Genetics of Mental Retardation Genetics, February 1, 2004; 166(2): 835 - 881. [Abstract] [Full Text] [PDF]

				F. Janody, J. D. Lee, N. Jahren, D. J. Hazelett, A. Benlali, G. I. Miura, I. Draskovic, and J. E. Treisman A Mosaic Genetic Screen Reveals Distinct Roles for trithorax and Polycomb Group Genes in Drosophila Eye Development Genetics, January 1, 2004; 166(1): 187 - 200. [Abstract] [Full Text] [PDF]

				M. E. Zuber, G. Gestri, A. S. Viczian, G. Barsacchi, and W. A. Harris Specification of the vertebrate eye by a network of eye field transcription factors Development, November 1, 2003; 130(21): 5155 - 5167. [Abstract] [Full Text] [PDF]

				C.-C. Jang, J.-L. Chao, N. Jones, L.-C. Yao, D. A. Bessarab, Y. M. Kuo, S. Jun, C. Desplan, S. K. Beckendorf, and Y. H. Sun Two Pax genes, eye gone and eyeless, act cooperatively in promoting Drosophila eye development Development, July 1, 2003; 130(13): 2939 - 2951. [Abstract] [Full Text] [PDF]

				L. Michaut, S. Flister, M. Neeb, K. P. White, U. Certa, and W. J. Gehring Analysis of the eye developmental pathway in Drosophila using DNA microarrays PNAS, April 1, 2003; 100(7): 4024 - 4029. [Abstract] [Full Text] [PDF]

				C. C. Zhu, M. A. Dyer, M. Uchikawa, H. Kondoh, O. V. Lagutin, and G. Oliver Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors Development, March 8, 2003; 129(12): 2835 - 2849. [Abstract] [Full Text] [PDF]

				J. Kronhamn, E. Frei, M. Daube, R. Jiao, Y. Shi, M. Noll, and A. Rasmuson-Lestander Headless flies produced by mutations in the paralogous Pax6 genes eyeless and twin of eyeless Development, March 4, 2003; 129(4): 1015 - 1026. [Abstract] [Full Text] [PDF]

				J. Lopez-Rios, K. Tessmar, F. Loosli, J. Wittbrodt, and P. Bovolenta Six3 and Six6 activity is modulated by members of the groucho family Development, January 1, 2003; 130(1): 185 - 195. [Abstract] [Full Text] [PDF]

				G. Goudreau, P. Petrou, L. W. Reneker, J. Graw, J. Loster, and P. Gruss Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype PNAS, June 25, 2002; 99(13): 8719 - 8724. [Abstract] [Full Text] [PDF]

				D. Arendt, K. Tessmar, M.-I. M. de Campos-Baptista, A. Dorresteijn, and J. Wittbrodt Development of pigment-cup eyes in the polychaete Platynereis dumerilii and evolutionary conservation of larval eyes in Bilateria Development, January 3, 2002; 129(5): 1143 - 1154. [Abstract] [Full Text] [PDF]

				F. Loosli, S. Winkler, C. Burgtorf, E. Wurmbach, W. Ansorge, T. Henrich, C. Grabher, D. Arendt, M. Carl, A. Krone, et al. Medaka eyeless is the key factor linking retinal determination and eye growth Development, October 15, 2001; 128(20): 4035 - 4044. [Abstract] [Full Text] [PDF]

				J Treisman Drosophila homologues of the transcriptional coactivation complex subunits TRAP240 and TRAP230 are required for identical processes in eye-antennal disc development Development, January 2, 2001; 128(4): 603 - 615. [Abstract] [PDF]

				Y. Onuma, S. Takahashi, M. Asashima, S. Kurata, and W. J. Gehring Conservation of Pax 6 function and upstream activation by Notch signaling in eye development of frogs and flies PNAS, February 19, 2002; 99(4): 2020 - 2025. [Abstract] [Full Text] [PDF]