spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 10 Aug 2005
doi: 10.1242/dev.01979

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.01979v1
132/18/4041    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pitsouli, C.
Right arrow Articles by Delidakis, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pitsouli, C.
Right arrow Articles by Delidakis, C.

Research article

The interplay between DSL proteins and ubiquitin ligases in Notch signaling


Chrysoula Pitsouli and Christos Delidakis*
* Author for correspondence (e-mail: delidaki{at}imbb.forth.gr)

Lateral inhibition is a pattern refining process that generates single neural precursors from a field of equipotent cells and is mediated via Notch signaling. Of the two Notch ligands Delta and Serrate, only the former was thought to participate in this process. We now show that macrochaete lateral inhibition involves both Delta and Serrate. In this context, Serrate interacts with Neuralized, a ubiquitin ligase that was heretofore thought to act only on Delta. Neuralized physically associates with Serrate and stimulates its endocytosis and signaling activity. We also characterize a mutation in mib1, a Drosophila homolog of mind bomb, another Delta-targeting ubiquitin ligase from zebrafish. Mib1 affects the signaling activity of Delta and Serrate in both lateral inhibition and wing dorsoventral boundary formation. Simultaneous absence of neuralized and mib1 completely abolishes Notch signaling in both aforementioned contexts, making it likely that ubiquitination is a prerequisite for Delta/Serrate signaling.


This article has been cited by other articles:


Home page
 JEMHome page
R. Song, Y.-W. Kim, B.-K. Koo, H.-W. Jeong, M.-J. Yoon, K.-J. Yoon, D.-J. Jun, S.-K. Im, J. Shin, M.-P. Kong, et al.
Mind bomb 1 in the lymphopoietic niches is essential for T and marginal zone B cell development
J. Exp. Med., October 27, 2008; 205(11): 2525 - 2536.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
E. Pavlopoulos, M. Anezaki, and E. M. C. Skoulakis
Neuralized is expressed in the {alpha}/{beta} lobes of adult Drosophila mushroom bodies and facilitates olfactory long-term memory formation
PNAS, September 23, 2008; 105(38): 14674 - 14679.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. Koutelou, S. Sato, C. Tomomori-Sato, L. Florens, S. K. Swanson, M. P. Washburn, M. Kokkinaki, R. C. Conaway, J. W. Conaway, and N. K. Moschonas
Neuralized-like 1 (Neurl1) Targeted to the Plasma Membrane by N-Myristoylation Regulates the Notch Ligand Jagged1
J. Biol. Chem., February 15, 2008; 283(7): 3846 - 3853.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
H. T. Nguyen, F. Voza, N. Ezzeddine, and M. Frasch
Drosophila mind bomb2 is required for maintaining muscle integrity and survival
J. Cell Biol., October 22, 2007; 179(2): 219 - 227.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
C. Roca and R. H. Adams
Regulation of vascular morphogenesis by Notch signaling
Genes & Dev., October 15, 2007; 21(20): 2511 - 2524.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
I. Geffers, K. Serth, G. Chapman, R. Jaekel, K. Schuster-Gossler, R. Cordes, D. B. Sparrow, E. Kremmer, S. L. Dunwoodie, T. Klein, et al.
Divergent functions and distinct localization of the Notch ligands DLL1 and DLL3 in vivo
J. Cell Biol., July 24, 2007; 178(3): 465 - 476.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
G. B. Thomas and D. J. van Meyel
The glycosyltransferase Fringe promotes Delta-Notch signaling between neurons and glia, and is required for subtype-specific glial gene expression
Development, February 1, 2007; 134(3): 591 - 600.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
C. Commisso and G. L. Boulianne
The NHR1 Domain of Neuralized Binds Delta and Mediates Delta Trafficking and Notch Signaling
Mol. Biol. Cell, January 1, 2007; 18(1): 1 - 13.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. Song, B.-K. Koo, K.-J. Yoon, M.-J. Yoon, K.-W. Yoo, H.-T. Kim, H.-J. Oh, Y.-Y. Kim, J.-K. Han, C.-H. Kim, et al.
Neuralized-2 Regulates a Notch Ligand in Cooperation with Mind Bomb-1
J. Biol. Chem., November 24, 2006; 281(47): 36391 - 36400.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
E. J. Hagedorn, J. L. Bayraktar, V. R. Kandachar, T. Bai, D. M. Englert, and H. C. Chang
Drosophila melanogaster auxilin regulates the internalization of Delta to control activity of the Notch signaling pathway
J. Cell Biol., May 8, 2006; 173(3): 443 - 452.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
L. Miele
Notch Signaling
Clin. Cancer Res., February 15, 2006; 12(4): 1074 - 1079.
[Full Text] [PDF]


© The Company of Biologists Ltd 2005