spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 11 Jan 2006
doi: 10.1242/dev.02236

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.02236v1
133/4/581    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wu, S.
Right arrow Articles by Capecchi, M. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wu, S.
Right arrow Articles by Capecchi, M. R.

Research article

Motoneurons and oligodendrocytes are sequentially generated from neural stem cells but do not appear to share common lineage-restricted progenitors in vivo


Sen Wu, Yuanyuan Wu, and Mario R. Capecchi*
* Author for correspondence (e-mail: mario.capecchi{at}genetics.utah.edu)

Olig gene expression is proposed to mark the common progenitors of motoneurons and oligodendrocytes. In an attempt to further dissect the in vivo lineage relationships between motoneurons and oligodendrocytes, we used a conditional cell-ablation approach to kill Olig-expressing cells. Although differentiated motoneurons and oligodendrocytes were eliminated, our ablation study revealed a continuous generation and subsequent death of their precursors. Most remarkably, a normal number of oligodendrocyte precursors are formed at day 12 of mouse development, after all motoneuron precursors have been killed. The data presented herein supports a sequential model in which motoneuron and oligodendrocyte precursors are sequentially generated in vivo from neuroepithelial stem cells, but do not share a common lineage-restricted progenitor.


This article has been cited by other articles:


Home page
 DevelopmentHome page
W. Yu, K. McDonnell, M. M. Taketo, and C. B. Bai
Wnt signaling determines ventral spinal cord cell fates in a time-dependent manner
Development, November 15, 2008; 135(22): 3687 - 3696.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. Dimou, C. Simon, F. Kirchhoff, H. Takebayashi, and M. Gotz
Progeny of Olig2-Expressing Progenitors in the Gray and White Matter of the Adult Mouse Cerebral Cortex
J. Neurosci., October 8, 2008; 28(41): 10434 - 10442.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. Delaunay, K. Heydon, A. Cumano, M. H. Schwab, J.-L. Thomas, U. Suter, K.-A. Nave, B. Zalc, and N. Spassky
Early Neuronal and Glial Fate Restriction of Embryonic Neural Stem Cells
J. Neurosci., March 5, 2008; 28(10): 2551 - 2562.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Sugimori, M. Nagao, N. Bertrand, C. M. Parras, F. Guillemot, and M. Nakafuku
Combinatorial actions of patterning and HLH transcription factors in the spatiotemporal control of neurogenesis and gliogenesis in the developing spinal cord
Development, April 15, 2007; 134(8): 1617 - 1629.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. Battiste, A. W. Helms, E. J. Kim, T. K. Savage, D. C. Lagace, C. D. Mandyam, A. J. Eisch, G. Miyoshi, and J. E. Johnson
Ascl1 defines sequentially generated lineage-restricted neuronal and oligodendrocyte precursor cells in the spinal cord
Development, January 15, 2007; 134(2): 285 - 293.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. C. Dugas, Y. C. Tai, T. P. Speed, J. Ngai, and B. A. Barres
Functional Genomic Analysis of Oligodendrocyte Differentiation
J. Neurosci., October 25, 2006; 26(43): 10967 - 10983.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. Gao and R. H. Miller
Specification of optic nerve oligodendrocyte precursors by retinal ganglion cell axons.
J. Neurosci., July 19, 2006; 26(29): 7619 - 7628.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2006