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About the Cover
Cover: Expression of the transcription factor Scleraxis in the tendons and connective tissue of the neck of a day 9 (stage 33) chick embryo. Scleraxis is an early marker for tendon progenitor cells, and continues to be transcribed in the mature tendons and connective tissue attaching the muscles to the skeletal elements. In the neck region, Scleraxis expression highlights the attachments of the muscles between the vertebrae, the intertransversales and multifidis cervicis (seen here as broad horizontal bands of blue staining); and the attachments of the muscles of the neck to the skull, the semispinalis (seen here as vertical lines of blue staining). Scleraxis thus provides a marker for following the specification and development of the tendons. For further details, see the article by R. Schweitzer, J. H. Chyung, L. C. Murtaugh, A. E. Brent, V. Rosen, E. N. Olson, A. Lassar and C. J. Tabin, pp. 3855-3866.
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